GdCl3 promoted synthesis of novel pyrimidine fused indazole derivatives and their anticancer activity

Autor:	B. P. V. Lingaiah, S. Gururaj, Balasubramanian Sridhar, T. Parthasarathy, Rajesh Pamanji, T. Yakaiah, L. R. Velatooru, Banda Narsaiah, C. Kurumurthy, J. Venkateswara Rao
Rok vydání:	2012
Předmět:	Indazole Pyrimidine U937 cell Stereochemistry Organic Chemistry Pharmacology toxicology Crystal structure In vitro chemistry.chemical_compound chemistry Docking (molecular) medicine General Pharmacology Toxicology and Pharmaceutics Etoposide medicine.drug
Zdroj:	Medicinal Chemistry Research. 21:4261-4273
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-011-9962-0
Popis:	The three component Grieco condensation of indazoles, aliphatic/aromatic aldehydes, and electron rich olefins in the presence of GdCl3 resulted in a novel pyrimidine fused indazoles in single pot under mild conditions. Representative examples were screened for in vitro anti-cancer activity and some of the compounds exhibited promising cytotoxic activity against U937 cell lines in comparable with standard drug etoposide. The data were further compared with structure-based investigations using docking studies with the crystal structure of Rho-kinase (2F2U) protein. The fitness values estimated by genetic algorithm were found to have a good correlation with the experimental inhibitory potencies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6aafa908c4f7e2f6e1b77e997b2ea45c https://doi.org/10.1007/s00044-011-9962-0 Zobrazit plný text záznamu Full text from SpringerLink