Studies on DNA Interactions and Biological Activities of Lanthanum(III) Complexes with 4-Quinoline Terpyridine and 1,10-Phenanthroline

Autor:	Vibha Vinayakumar Bhat, P. R. Chetana, Mohan Appasaheb Dhale, D.R. Navya, B.S. Srinatha
Rok vydání:	2019
Předmět:	inorganic chemicals 010405 organic chemistry Phenanthroline Quinoline Dna interaction food and beverages chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Polymer chemistry Lanthanum Terpyridine
Zdroj:	Asian Journal of Chemistry. 31:1265-1274
ISSN:	0975-427X 0970-7077
Popis:	A series of lanthanum(III) complexes [La(4-qtpy)2(NO3)2](NO3) (1), [La(4-qtpy)3(NO3)](NO3)2 (2), [La(4-qtpy)(phen)(NO3)2](NO3) (3) and [La(4-qtpy)(phen)2(NO3)2](NO3) (4) (4-qtpy = 4′-[(4-quinoline)-2,2′;6′,2′′-terpyridine]) were synthesized and characterized. The cyclic voltammetric studies revealed that the complexes 1 and 3 are redox active. UV-visible absorption spectral studies and viscosity measurements revealed that complexes bind to DNA through intercalation. Complexes 1 and 3 have shown the highest binding propensity (Kb = 4.241 + 0.2 × 106 for 1 and 1.492 + 0.2 × 106 for 3). The results of chemical nuclease studies revealed that the complexes 3 and 4 have shown maximum chemical nuclease activity in the presence of H2O2 and the mechanism involves hydroxyl radicals. The antibacterial activities of the complexes 1 to 4 were tested against Gram positive and Gram negative bacteria in which complex 3 shows comparable results with the standard antibiotic tetracycline. The cytotoxic activities of 4-qtpy and complex 4 were done by MTT assay against HeLa cell lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6aabd3a126a78dd36f73fbb7d8bdae02 https://doi.org/10.14233/ajchem.2019.21889 Zobrazit plný text záznamu