Transition metal-free, iodide-mediated domino carbonylation–benzylation of benzyl chlorides with arylboronic acids under ambient pressure of carbon monoxide
| Autor: | Qian Zhao, Huichun Zhang, Fengli Jin, Xin Zhang, Yanzhen Zhong, Wei Han |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Iodide Halide 010402 general chemistry 01 natural sciences Pollution Domino 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Transition metal Environmental Chemistry Organic chemistry Carbonylation Ambient pressure Carbon monoxide |
| Zdroj: | Green Chemistry. 18:2598-2603 |
| ISSN: | 1463-9270 1463-9262 |
| DOI: | 10.1039/c6gc00017g |
| Popis: | A conceptually distinct approach toward the synthesis of 1,2,3-triarylpropan-1-one by NaI-catalyzed domino carbonylation–benzylation of unactivated benzyl chlorides with arylboronic acids has been developed under ambient pressure of CO gas. The novel method represents a significant improvement over the traditional palladium-catalyzed carbonylation: the catalyst NaI is abundant, inexpensive, and bench stable, the reaction conditions are much milder, and the use of ligands and the costly need to remove metallic impurities from the end products are avoided. This apparently transition-metal-free process offers a new strategy for carbonylative cross-coupling reactions of C(sp3) halides. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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