ChemInform Abstract: Hypervalent Iodine Oxidation of α-Substituted 2,4-Dihydroxyacetophenones: Synthesis of Novel o-Iodophenoxy Ethers via Rearrangement of Iodonium Ylides

Autor:	Om Prakash, M. P. Tanwar, Vijay Sharma
Rok vydání:	2010
Předmět:	PIDA Chemistry Reagent Hypervalent molecule chemistry.chemical_element General Medicine Iodine Medicinal chemistry
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200001096
Popis:	α-Substituted 2,4-dihydroxyacetophenones (1a-1i) have been oxidized with phenyliodonium diacetate (PIDA) under three conditions (i) PIDA-KOH-MeOH (basic) at 0°C, (ii) PIDA-MeOH (neutral) at reflux temperature, and (iii) PIDA-AcOH (acidic) at reflux temperature, to afford novel o-iodophenoxy ethers (4a-4i) via rearrangement of respective iodonium ylides (5a-5i). Key words: hypervalent iodine reagents, phenyliodonium diacetate, α-substituted 2,4-dihydroxyacetophenones, α-substituted 2-hydroxy-3-iodo-4-phenoxyacetophenones, iodonium ylides rearrangement
Databáze:	OpenAIRE
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