Three monoclonal IgG components, an IgG4(Λ), an IgG2(κ) and an IgG1/IgG3 (κ) Gm(f,b) hybrid, in a single myeloma patient
| Autor: | N Milosevic-Jovcic, L Tosic, Nada Suvajdzic, L Jovanovic, Z Rolovic, Radosević N, Mirjana Gotic, N Dovezenski |
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| Rok vydání: | 2009 |
| Předmět: |
Idiotype
0303 health sciences Hematology General Medicine Biology medicine.disease Isotype Molecular biology Allotype Subclass 3. Good health 03 medical and health sciences 0302 clinical medicine Immunopathology Immunology medicine biology.protein Antibody Kappa Multiple myeloma 030304 developmental biology 030215 immunology |
| Zdroj: | European Journal of Haematology. 54:288-295 |
| ISSN: | 1600-0609 0902-4441 |
| DOI: | 10.1111/j.1600-0609.1995.tb00688.x |
| Popis: | An unusual triclonal IgG combination in the serum of a 56-year old male with clinical stage IIIB multiple myeloma is reported. The patient initially had an IgG4(lambda) monoclonal protein in his serum and later developed an IgG2(kappa) and an IgG (kappa) which possessed the characteristics of both IgG1 and IgG3 subclasses with an unusual combination of allotypic markers. Three M-proteins did not share idiotypic determinants. A rare class-switch recombination followed by mutation has been considered as a possible mechanism leading to this combination. |
| Databáze: | OpenAIRE |
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