Formulation and in-vivo evaluation of nanosponges based tramadol HCL C/R tablets using design of experiment
| Autor: | Duggi Vamshidhar Reddy, Ambati Sambashiva Rao |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | International journal of health sciences. :10696-10715 |
| ISSN: | 2550-696X 2550-6978 |
| Popis: | The current study was aimed to develop a controlled release formulation of tramadol utilizing the cyclodextrin based nanosponges. Box-Behnken design was employed to study the effect of each independent variable on dependent variables. Five types of nanosponges from β-cyclodextrin (NS1-NS5) were purposely designed. The prepared nanosponges by freeze drying method were characterized and formulated into tablets and evaluated for in-vitro and in-vivo studies. The particle sizes of tramadol-nanosponges are in between 34.38 to 134.26 nm, encapsulation efficiency of 41.13-86.72% and drug release% at 6h of 52.34-81.12%. More than 90 % of drug was found to be released from nanosponge formulations. The FTIR, DSC and XRPD studies confirmed the interaction of Tramadol with nanosponges. The nanosponges Cmax of 915.24±1.67 ng/ml was significantly higher (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|