Unusual oximes with anti-inflammatory activities from Glycosmis craibii
| Autor: | Shou-Yuan Wu, Ziming Chen, Zhong-Liu Zhou, Guo-Ling Huang, Li-Ping Huang, Qi Zhou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Lipopolysaccharide
biology medicine.drug_class Plant Science Inhibitory postsynaptic potential biology.organism_classification Biochemistry Anti-inflammatory Nitric oxide chemistry.chemical_compound chemistry In vivo Ic50 values medicine Mouse Macrophage Agronomy and Crop Science Glycosmis Biotechnology |
| Zdroj: | Phytochemistry Letters. 44:202-205 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2021.06.025 |
| Popis: | Two new aldoximes A–B (1−2), and two known analogues (3−4), were identified from ethanolic extracts of Glycosmis craibii. The structures of new compounds 1−2 were unambiguously elucidated based on spectroscopic methods. All isolated aldoximes were evaluated for their anti-inflammatory activity in vivo. Compounds 1−4 displayed remarkable inhibitory effects against nitric oxide (NO) production stimulated by lipopolysaccharide in mouse macrophage RAW 264.7 cells with the IC50 values ranging from 2.38 ± 0.08–8.43 ± 0.21 μM. |
| Databáze: | OpenAIRE |
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