Expression of odontogenic ameloblast-associated protein, amelotin, ameloblastin, and amelogenin in odontogenic tumors: immunohistochemical analysis and pathogenetic considerations
| Autor: | Renata Callestini Felipini, Suzana Cantanhede Orsini Machado de Sousa, Glauco Issamu Miyahara, Marcelo Macedo Crivelini |
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| Rok vydání: | 2011 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Adenomatoid odontogenic tumor Odontogenic tumor Biology medicine.disease Calcifying epithelial odontogenic tumor Pathology and Forensic Medicine Odontogenic Fibroma stomatognathic diseases Ameloblastic fibroma Odontoma stomatognathic system Otorhinolaryngology Odontogenic cyst medicine Periodontics Oral Surgery Ameloblastoma |
| Zdroj: | Journal of Oral Pathology & Medicine. 41:272-280 |
| ISSN: | 0904-2512 |
| Popis: | Screening for expression of amelogenesis-related proteins represents a powerful molecular approach to characterize odontogenic tumors and investigate their pathogenesis. In this study, we have examined the presence and distribution of odontogenic ameloblast-associated protein (ODAM), amelotin (AMTN), ameloblastin (AMBN), and amelogenin (AMEL) by immunohistochemistry in samples of adenomatoid odontogenic tumor (AOT), calcifying epithelial odontogenic tumor (CEOT), developing odontoma, ameloblastoma, calcifying cystic odontogenic tumor (CCOT), ameloblastic fibroma (AF), myxoma, odontogenic fibroma (OF), and reduced enamel epithelia (REE). Positive results were obtained in those tumors with epithelial component, except for AF, OF, and ameloblastoma. ODAM was found around mineralized structures (dystrophic calcifications) and CEOT's amyloid, whereas AMTN stained the eosinophilic material of AOTs. The CCOT transitory cells to ghost cells were strongly positive with all proteins except AMEL, and the REE as well as odontomas showed immunoexpression for ODAM, AMTN, AMBN, and AMEL similar to those found in normal rat tooth germs. Based on these results, some histopathogenetic theories were formulated. |
| Databáze: | OpenAIRE |
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