Synthesis and structure-activity relationships of novel antiseptics
| Autor: | Koichi Yasumura, Mikio Kikuchi, Kinue Ohguro, Hiroshi Ishikawa, Hidetsugu Tsubouchi |
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| Rok vydání: | 1997 |
| Předmět: |
Plate method
Gram-negative bacteria biology medicine.drug_class Chemistry Gram-positive bacteria Organic Chemistry Clinical Biochemistry Pharmaceutical Science biology.organism_classification Biochemistry Combinatorial chemistry Chemical synthesis Antiseptic Drug Discovery medicine Molecular Medicine Molecular Biology Antibacterial agent |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 7:1721-1724 |
| ISSN: | 0960-894X |
| Popis: | For the purpose of developing new antiseptics, we searched for compounds having high biocidal activity covering both gram-positive and gram-negative bacteria. Accordingly, we designed 1,5-disubstituted biguanides and synthesized them using two alternative efficient reaction schemes. The bactericidal activity of these biguanides was assayed by the micro titration plate method. Among the biguanides synthesized, 3,4-dichlorobenzyl derivatives were found to exhibit particularly high bactericidal activity. Ultimately, compound 11 was chosen as a candidate novel antiseptic, which is currently under continued evaluation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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