Beta-Endorphin and Opiate Receptor Changes in Acute and Chronic Models of Hepatic Encephalopathy

Autor:	P. Zanoli, A. M. Russo, Elvira Ventura, C. Vezzelli, M. Baraldi, M. L. Zeneroli
Rok vydání:	1989
Předmět:	medicine.medical_specialty business.industry Encephalopathy medicine.disease chemistry.chemical_compound Endocrinology Fulminant hepatic failure chemistry Internal medicine Morphine Medicine beta-Endorphin Opiate business Receptor Hepatic encephalopathy medicine.drug Endogenous opioid
Zdroj:	Hepatic Encephalopathy ISBN: 9781461288510
DOI:	10.1007/978-1-4612-4506-3_32
Popis:	In order to gain information on the mechanisms which induce a supersensitivity to morphine administration in patients with acute and chronic liver failure, the levels of the endogenous opioid beta-endorphin was studied in plasma and in two brain areas of rats and dogs at two different levels of encephalopathy. In the dog model of portal-systemic encephalopathy the binding characteristics of opiate receptors in hypothalamus and cortex were studied. Herein we report that during the development of encephalopathy there are changes in the levels of beta-endorphins and in the opiate receptor densities which taken overall might explain the altered responce to morphine administration in man.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6a78ee96f29f55170d5226ad3e3277ce https://doi.org/10.1007/978-1-4612-4506-3_32 Zobrazit plný text záznamu