Long-Term Lipid Profiles with Isradipine and Hydrochlorothiazide Treatment in Elderly Hypertensive Patients
| Autor: | Katherine P. Matthews, Larry Lopez, Dean L. McCarley, Gerald H. Stein, Gary P. Quay, Ricardo E. Bannatyne |
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| Rok vydání: | 1990 |
| Předmět: |
Pharmacology
medicine.medical_specialty Isradipine Cholesterol business.industry Antagonist Diastole chemistry.chemical_compound Endocrinology Blood pressure Hydrochlorothiazide chemistry Internal medicine Concomitant medicine lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine Prospective cohort study business medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 15:S90-S92 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-199000151-00019 |
| Popis: | Lipid profiles were determined in 56 elderly patients with benign essential hypertension during an open-label 1-year study of the safety and efficacy of isradipine, a new calcium antagonist, in controlling blood pressure. Patients with diastolic blood pressures between 96 and 115 mm Hg were titrated with isradipine (mean dose of 11 mg/day) to reduce blood pressure to less than 90 mm Hg. Ten of these patients received concomitant hydrochlorothiazide (HCTZ) 50 mg/day for additional control. Sera were analyzed using standard methods at the end of a 2- to 4-week washout period, and at the end of Months 6 and 12, for total cholesterol (CHOL) and HDL- and LDL-cholesterol. Changes in lipid values (mg/dl) from baseline to 12 months with isradipine alone (n = 38) were as follows: CHOL, -7.5; HDL, +3.9 (p less than 0.05); LDL, -6.2; CHOL/HDL, -0.6 (p less than 0.05). For patients receiving concomitant HCTZ (n = 9), the changes were as follows: CHOL, -4.9; HDL, +3.4; LDL, -16.8; CHOL/HDL, -0.4. In conclusion, isradipine alone was associated with significant improvements in HDL cholesterol and total CHOL/HDL ratio. Lipid profiles of patients receiving isradipine and HCTZ were minimally affected. Favorable lipid changes with isradipine suggest that it may have advantages in the treatment of hypertensive patients. |
| Databáze: | OpenAIRE |
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