Prophylactic Administration of Curcumin Abates the Incidence of Hypobaric Hypoxia Induced Pulmonary Edema in Rats: A Molecular Approach
| Autor: | Titto Mathew, Himadri Patir, Sarada S.K. Sagi |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty Lung business.industry Pharmacology Hypoxia (medical) medicine.disease medicine.disease_cause Pulmonary edema Extravasation chemistry.chemical_compound medicine.anatomical_structure chemistry Edema High-altitude pulmonary edema medicine Curcumin medicine.symptom business Oxidative stress |
| Zdroj: | Journal of Pulmonary & Respiratory Medicine. |
| ISSN: | 2161-105X |
| DOI: | 10.4172/2161-105x.1000164 |
| Popis: | Background and purpose: High Altitude Pulmonary Edema (HAPE) is a severe high altitude illness with serious pulmonary manifestations. The present study reports benefits of prophylactic administration of curcumin in prevention of hypoxia induced pulmonary edema. Experimental approach: Male Sprague Dawley rats (n=6 per group) were exposed to a stimulated hypobaric hypoxia at 7620 m for 6 h. The groups studied were (I) Normoxia, (II) Hypoxia (6 h), (III) Normoxia+curcumin (50 mg/kg BW) and (IV) Hypoxia+curcumin (50 mg/kg BW). Curcumin at 50 mg/kg BW, given orally 1 h prior to hypoxia exposure was considered from dose dependent studies as the optimum dose, due to significant reduction in the level of lung water content and lung transvascular leakage (p |
| Databáze: | OpenAIRE |
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