| Autor: |
Jayden Mckinnon, Heloisa Milioli, Carley Purcell, Christine Chaffer, Bishoy Wadie, Theodore Alexandrov, Todd Mitchell, Shane Ellis |
| Rok vydání: |
2023 |
| Popis: |
Matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) of metabolites can reveal how metabolism is altered throughout heterogeneous tissues. Here MALDI-MSI has been coupled with laser post-ionsiation (MALDI-2) and applied to the MSI of metabolites for the first time. Using mouse kidney and tumour-bearing liver tissue, MALDI-2 significantly improved metabolite coverage and the detection sensitivity of many metabolites. This approach provides a significant advancement for metabolite MSI, enabling the metabolic environment of tissues to be imaged at increased levels of detail. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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