The Effects of Low Doses of n-3 Fatty Acid Supplementation on Blood Pressure in Hypertensive Subjects
| Autor: | Colleen C. Deck, Kenneth L Radack, Gertrude Huster |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Supine position business.industry Linoleic acid Diastole Fatty acid Fish oil Crossover study chemistry.chemical_compound Blood pressure Endocrinology chemistry Internal medicine Internal Medicine medicine Cardiology Arterial blood business |
| Zdroj: | Archives of Internal Medicine. 151:1173 |
| ISSN: | 0003-9926 |
| DOI: | 10.1001/archinte.1991.00400060097017 |
| Popis: | The potential antihypertensive effects after prolonged use of small doses of fish oils remain undefined. Therefore, we conducted a randomized, double-blind, controlled crossover study comparing low doses of n-3 fatty acid supplementation with n-6 fatty acids on blood pressure in 33 subjects with mild hypertension. After a 6-week stabilization period, subjects ingested either 2.04 g/d of n-3 fatty acids or safflower oil (4.8 g/d of linoleic acid) for 12 weeks, then crossed over to the alternative encapsulated oil for another 12 weeks, after a 4-week washout period. All antihypertensive drug therapy had been discontinued. For the combined data, there were significant reductions from pretreatment values for supine diastolic ( — 2.4 mm Hg) and sitting systolic (—4.1 mm Hg) blood pressure after fish oil; no significant changes occurred after safflower oil control. Compared with safflower oil, fish oil supplementation was associated with a statistically significant reduction in mean supine diastolic blood pressure of 3.7 mm Hg (95% confidence interval, —7.3 and 0.1). Sitting diastolic and mean arterial pressures showed a sequence effect; therefore,only the initial period was used in an analysis of their responses. There were significant decreases from pretreatment values for sitting diastolic ( — 4.4 mm Hg), mean arterial (—5.1 mm Hg), and systolic (—6.5 mm Hg) blood pressure after fish oil. The differences between groups after the 12-week period remained statistically significant for sitting diastolic and sitting mean arterial blood pressures. No adverse changes were noted in plasma levels of lipid-related measures. (Arch Intern Med. 1991;151:1173-1180) |
| Databáze: | OpenAIRE |
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