Bioavailability, biodistribution, and toxicity of biozn-aas: a new zinc source. comparative studies in rats
| Autor: | Ettlin Eduardo Walter, José Boccio, Tomas De Paoli, Ricardo A. Caro, María I. Sarabia, Marcela Zubillaga, María J. Salgueiro, A. Hager, R. Weill, Alexis Lysionek |
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| Rok vydání: | 2000 |
| Předmět: |
Biodistribution
medicine.medical_specialty Nutrition and Dietetics Endocrinology Diabetes and Metabolism chemistry.chemical_element Zinc medicine.disease Median lethal dose Bioavailability chemistry.chemical_compound Endocrinology chemistry Zinc hydroxide Internal medicine Toxicity Gluconic acid Zinc deficiency medicine |
| Zdroj: | Nutrition. 16:762-766 |
| ISSN: | 0899-9007 |
| DOI: | 10.1016/s0899-9007(00)00379-8 |
| Popis: | Food fortification with a proper zinc compound is an economic and effective strategy to prevent zinc deficiency. BioZn-AAS, a zinc gluconate stabilized with glycine, was compared with zinc sulfate (reference standard), zinc hydroxide, and zinc gluconate, all of them labeled with (65)Zn. This preclinical study was performed on Sprague-Dawley rats of both sexes, and the administered dose was 85 microg/kg of zinc. Bioavailability studies showed that absorption of BioZn-AAS was not statistically different than absorption from other sources in female rats (25.65% +/- 2.20% for BioZn-AAS, 28.24% +/- 4. 60% for ZnSO(4), 24.91% +/- 4.02% for Zn[OH](2), and 25.51% +/- 2. 70% for Zn-gluconate). In the case of the male rats, absorption of BioZn-AAS (27.97% +/- 4.20%) was higher (P |
| Databáze: | OpenAIRE |
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