| Popis: |
Background: We aimed to investigate early arteriosclerosis and its risk factors in populations with prediabetes and new-onset diabetes. Materials and Methods: A total of 148 participants without known diabetes mellitus were assigned to three groups: normal glucose tolerance (NGT); impaired glucose regulation (IGR), also known as prediabetes; and new-onset type 2 diabetes mellitus (T2DM) through an oral glucose tolerance test (OGTT). The insulin resistance index was assessed using the homeostasis model (HOMA-IR). An enzyme-linked immunosorbent assay was used to determine the expression level of the fibroblast growth factor 21 (FGF21). An arteriosclerosis detector was used to measure the brachial-ankle pulse wave velocity (baPWV) and the ankle-brachial index (ABI). The baPWV, ABI and FGF21 were used to assess early arteriosclerosis. Results: Significant differences in age, systolic blood pressure (SBP), fasting plasma glucose (FPG), 2-hour plasma glucose (2hPG), 2-hour insulin (2hINS) and HOMA-IR were found between the NGT group and the prediabetic and new-onset diabetic groups. All except 2hINS showed an increasing trend. The FGF21 and the baPWV increased from the NGT group to prediabetic and the new-onset diabetic group, but no significant difference was noted in the ABI. The age, SBP, diastolic blood pressure (DBP), FPG, 2hPG and FGF21 positively correlated with the baPWV. The BMI, SBP, DBP, FPG, 2hPG and HOMA-IR positively correlated with the ABI. The age, BMI, FPG, FGF21 and HOMA-IR were independent risk factors for the baPWV, and the SBP and the HOMA-IR were independent risk factors for ABI. Conclusions: Patients with prediabetes and new-onset diabetes had more significant early arteriosclerosis. The blood glucose and insulin resistance index were independent risk factors for early arteriosclerosis. |
