ChemInform Abstract: 1-[2-(Diphenylmethoxy)ethyl]-2-methyl-5-nitroimidazole: A Potent Lead for the Design of Novel NNRTIs

Autor:	Francesca Montis, Tiziana Marceddu, Marino Artico, Silvio Massa, Paolo La Colla, Romano Silvestri
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Nitroimidazole chemistry Stereochemistry Nitro Imidazole General Medicine Ring (chemistry)
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200020105
Popis:	A novel family of non-nucleoside reverse transcriptase inhibitors (NNRTIs) active at submicromolar concentrations was discovered. The new derivatives are 1-[2-(diarylmethoxy)ethyl]imidazoles bearing substituents both at benzene and imidazole rings. The most potent derivatives were those having nitro and methyl groups as substituents in the imidazole ring. Among 10 test derivatives compound 6d was found to be as potent as nevirapine and was selected as a lead for further studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6a5968780fc4e4cb139f52e7a6944456 https://doi.org/10.1002/chin.200020105 Zobrazit plný text záznamu Plný text