Virtual 3D microscope and magnified 3D print for naked eye analyses of alveoli and alveolar duct structures by Heitzman lung specimen with micro CT

Autor: Hiroshi Natori, Hirotoshi Homma, Hiroyuki Koba, Masahiro Oda, Kensaku Mori, Hiroki Takahashi, Masaki Mori, Hirotsugu Takabatake
Rok vydání: 2017
Předmět:
Zdroj: Imaging.
DOI: 10.1183/1393003.congress-2017.pa3747
Popis: Introduction: and Aims Three dimensional structures of the peripheral lung are difficult to know by serial images of histological slides. Magnified 3D printed peripheral lung model were made by micro CT of lung specimen. Methods: Micro CT images of inflated fixed lung specimen by Heitzman’s method were obtained. Micro-NewVES application created by co-author KM was used for virtual observation. Magnified model of the specimen was made by 3D printer. Results: Virtual micro-endoscopic view disclosed bronchioles to orifices of respiratory bronchioles. Ring structure was found at the alveolar duct. Magnified 3D print of the lung specimen showed structures of alveolar ducts and alveoli. There was a duct space surrounded by 6 alveoli that recognized as a unit. The view of the alveolar duct showed the alveolar ring unit that sequentially connected one after another. Clinical CT of the magnified print model also showed clear unit structures. Conclusions: Magnified 3D structures of alveolar ducts were found. This method may apply for analysis of COPD and many diseases with parenchymal involvement. References Natori H, Mori M, Takabatake H, Koba H, Mori K, Toriwaki J: Study on three-dimensional display and navigation of the bronchiolo-alveolar structure of the lung by sub-macroscopic virtual bronchoscopy. European Congress of Radiology 2004; B-915, European Radiology 14 (suppl 2): p329.
Databáze: OpenAIRE