DA-9701 improves colonic transit time and symptoms in patients with functional constipation: A prospective study

Autor: Kwang An Kwon, Kyoung Oh Kim, Su Young Kim, Yoon Jae Kim, Su Ji Kim, Sung Han Choi, Jung Ho Kim, Dong Kyun Park, Hyun Sun Woo, Jun-Won Chung
Rok vydání: 2017
Předmět:
Zdroj: Journal of Gastroenterology and Hepatology. 32:1943-1948
ISSN: 0815-9319
DOI: 10.1111/jgh.13807
Popis: Background and Aim DA-9701, a newly developed prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber, has been shown to effectively treat functional dyspepsia. Recently, it has also been suspected to improve gastrointestinal motor function. The aims of this study were to assess the effect of DA-9701 on colonic transit time (CTT) and symptoms of functional constipation. Methods Thirty-three patients with functional constipation based on the Rome III criteria were prospectively enrolled. The patients received 30-mg DA-9701 three times a day for 24 days. CTT was estimated initially and at the end of treatment. Symptoms such as spontaneous bowel movements, straining, stool form, feeling of incomplete emptying and anorectal blockage, abdominal discomfort and pain, overall defecation satisfaction, and incidence of adverse events were also analyzed. Results Twenty-seven patients completed the study. DA-9701 was associated with a significantly reduced CTT from 34.9 ± 17.6 to 23.7 ± 19.1 h (P = 0.001). Segmental CTT also significantly decreased after treatment (right CTT: from 16.8 [0.0–28.8] to 6.0 [0.0–25.2] hours, P
Databáze: OpenAIRE
Externí odkaz: