Increased expression of interleukin-23 associated with progression of colorectal cancer
| Autor: | Chang-Chun Hsiao, Jiin-Haur Chuang, Hong-Hwa Chen, Shao-Lun Yen, Hsuan-Ying Huang, Wan-Hsiang Hu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty business.industry Proportional hazards model Colorectal cancer Hazard ratio General Medicine medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Medicine Immunohistochemistry Surgery Stage (cooking) business Pathological Survival rate Survival analysis |
| Zdroj: | Journal of Surgical Oncology. 115:208-212 |
| ISSN: | 0022-4790 |
| DOI: | 10.1002/jso.24505 |
| Popis: | BACKGROUND AND OBJECTIVES The prognostic significance of interleukin-23 in colorectal cancer remains unclear. We designed this study to investigate the association between colorectal cancer and interleukin-23 (IL-23) or interleukin-23 receptor (IL-23R) expression and the resulting clinical features and survival. METHODS Immunohistochemical staining was performed for IL-23 and IL-23R in colorectal cancer samples. H-score was calculated to compare the expression of IL-23 and IL-23R. The median of H-score was used as the cut-off value to separate patients into high or low expression groups. The differences in clinicopathological features were evaluated. Cox regression hazard ratios were used for survival analysis. RESULTS A total of 129 colorectal cancer patients were enrolled. H-score for the late TNM stage patients was higher than that for the early TNM stage patients (P = 0.002). Patients with high IL-23 expression were associated with advanced pathological T category (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text