Coumarins and acridone alkaloids with α-glucosidase inhibitory and antioxidant activity from the roots of Paramignya trimera
| Autor: | Duong Hoang Trinh, Hiep D. Nguyen, Binh T.D. Trinh, Ly Dieu Ha, Phuong T. Tran, Lien-Hoa D. Nguyen, Hieu T. Nguyen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
biology 010405 organic chemistry Chemistry DPPH Stereochemistry medicine.medical_treatment Alkaloid Plant Science biology.organism_classification Ascorbic acid 01 natural sciences Biochemistry 0104 chemical sciences Acridone 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Rutaceae medicine Agronomy and Crop Science Two-dimensional nuclear magnetic resonance spectroscopy Biotechnology Acarbose medicine.drug |
| Zdroj: | Phytochemistry Letters. 35:94-98 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2019.10.010 |
| Popis: | Three new compounds comprising two coumarins, paramicoumarins A (1) and B (2), and an acridone alkaloid, paramiacridone (3), together with seven known compounds, were isolated from the n-hexane extract of the roots of Paramignya trimera (Rutaceae). Their structures were elucidated using spectroscopic methods, mainly 1D and 2D NMR. α-Glucosidase inhibition and DPPH radical scavenging activity of the compounds and fifteen other compounds previously isolated from the roots of this plant were evaluated. Most of the compounds exhibited stronger α-glucosidase inhibitory activity than acarbose, the positive control (IC50 = 223.0 μM), and the new compounds paramiacridone (3) and paramicoumarin B (2) showed good inhibitory effect (IC50 = 62.5 and 65.5 μM, respectively). In the DPPH test for radical scavenging activity, the acridone alkaloid glycocitrin III (17) exhibited the highest antioxidant activity (IC50 = 84.2 μM) (compared with the positive control, ascorbic acid, IC50 = 152.7 μM). |
| Databáze: | OpenAIRE |
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