A Study on the Liver Function Indices LU3 and LU15 with 99mTc-GSA

Autor:	Hiroyuki Shinohara, Shin Hasebe, Fumiake Yamashita, Masahiro Kawakubo, Yoshio Kuniyasu, Yasuo Niio, Makoto Miyashita, Jun Kuwayama, Katunori Yoshioka
Rok vydání:	1994
Předmět:	medicine.medical_specialty Radiation Cirrhosis business.industry 99mtc gsa Blood flow medicine.disease Endocrinology Internal medicine medicine Whole Body Scan Poor correlation Liver function Compartment (pharmacokinetics) Receptor business
Zdroj:	RADIOISOTOPES. 43:346-349
ISSN:	1884-4111 0033-8303
Popis:	Correlation of LU3 (LU15) which represents the cumulative uptake of99mTc-GSA from 3 (15) to 4 (16) min after injection and hepatic blood flow or receptor quantity was studied. The subjects consisted of 14 patients, including 13 patients with liver cirrhosis or chronic hepatitis and 1 patient with normal liver. LU3 and L U15 showed a good correlation with the ratio of99mTc-GSA binding to receptor and the total injected99mTc-GSA, estimated by whole body scan. LU3 and LU15 also well correlated with the maximal removal rate by nonlinear compartment model, on the other hand, they showed a poor correlation with the hepatic blood flow. It was concluded that LU3 and LU15 chiefly reflect the amount of receptors in the liver.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6a42deaf5dc19a484bbc77982eec4fea https://doi.org/10.3769/radioisotopes.43.346 Zobrazit plný text záznamu