Hyperdiploidy and duplication of der(11)ins(10;11)(p12;q23q14) in acute myeloid leukemia withMLL/MLLT10fusion gene

Autor:	Shinnosuke Ueda, Yuji Nakamachi, Katsuya Yamamoto, Hironobu Minami, Hiroshi Matsuoka, Kimikazu Yakushijin, Atsuo Okamura, Seiji Kawano
Rok vydání:	2013
Předmět:	Cancer Research Pathology medicine.medical_specialty Myeloid CD34 Myeloid leukemia Chromosomal translocation Hematology Biology medicine.disease Leukemia medicine.anatomical_structure Oncology hemic and lymphatic diseases medicine Idarubicin Bone marrow Hyperdiploidy medicine.drug
Zdroj:	Leukemia & Lymphoma. 54:2055-2058
ISSN:	1029-2403 1042-8194
Popis:	myeloperoxidase and α -naphthyl butyrate esterase staining. Surface marker analyses with three-color fl ow cytometry by CD45/side scatter gating revealed that immature cells (76.9% of all bone marrow cells) were positive ( 20%) for CD4 (25.3%), CD13 (86.7%), CD33 (100.0%) and CD34 (99.2%). Considering cytogenetic abnormalities and MLL rearrangements described below, we made a diagnosis of AML with a variant MLL translocation in the World Health Organization classification, or AML M4 in the French – American – British classification. Induction therapy with idarubicin and cytosine arabinoside was started, and the patient achieved a hematological complete remission (CR). However, she suffered from severe pneumonia and heart failure, and died of multiple organ failure 2 months after the initial diagnosis. Chromosome analysis of the bone marrow cells at the initial diagnosis showed 50,XX, 4, 6, 8,?t(10;11)(p12;q14)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6a3d8c47310f7e6c59648ad764275aae https://doi.org/10.3109/10428194.2012.762094 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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