Inflammation-related oxidative stress in white adipose tissues of an inbred obese pig
| Autor: | Z. Y. Jiang, Z. M. Tian, K. G. Gao, Y. J. Hu, X. F. Yang, Y. Q. Qiu, X. Y. Ma, L. Wang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry Adipose tissue macrophages Adipose tissue 030209 endocrinology & metabolism Inflammation White adipose tissue medicine.disease_cause White (mutation) 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Internal medicine medicine medicine.symptom business Oxidative stress |
| Zdroj: | Annals of Animal Science. 17:433-446 |
| ISSN: | 2300-8733 |
| Popis: | The uneven development of adipose tissues reflects a differential occurrence of biological events in vivo while the underlying molecular mechanism remains largely unknown. In the present study, the in vivo inflammatory status of an inbred obese porcine model, Lantang pig, was assessed, aiming to provide evidence for obesity biology. Compared with genetically lean pigs (crossbred, Duroc × Landrace × Large White), Lantang pigs exhibited a larger amount of ultra large adipocytes in subcutaneous adipose tissue accompanied with higher expression of macrophage/monocytes markers and pro-inflammatory genes (TLR4, CD14, CD11β, MCP1, TNFα, IL1β and IL6) and lower expression of cellular antioxidant enzymes (SOD1, 2 and 3). Plasma concentrations of LPS and TNF-α were also higher in Lantang pigs than in lean pigs. Among adipose tissues of Lantang pigs, the subcutaneous tissue had the most abundant expression of inflammation related genes (TLR4, CD14, TNFα and IL6) and the lowest level of cellular antioxidant genes (SOD 1 and 2), while the perirenal adipose tissue had opposite profile. Significant activation of p38 MAPK pathway was indicated by increased phosphorylation of p38 in the subcutaneous adipose tissue of Lantang pigs. Collectively, the bacteria-derived LPS induced inflammation-associated oxidative stress indeed exists in adipose tissues of Lantang pig, and the differential expressions of inflammatory and antioxidant genes, to some extent, account for the uneven development of the adipose tissue within bodies. |
| Databáze: | OpenAIRE |
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