| Autor: |
Hong-Yu Zhi, Jiaoling Ning, Jian Huang, Yujie Li, Kaizhi Lu, Congwen Yang, Zheng-Yuan Xia, Bin Yi, Xi Tang, Karine Belguise, Yihui Yang, Xiaobo Wang, Jianteng Gu, Yang Chen |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.10.06.327874 |
| Popis: |
As important mediators of intercellular communication, exosome have can modulate various cellular functions by transferring a variety of intracellular components to target cells. However, little is known about the role of exosome-mediated communication between distant organs. Hepatopulmonary syndrome (HPS) is a severe lung injury caused by chronic liver disease. A new long noncoding RNA (lncRNA) PICALM-AU1 was found and upregulated in the liver of HPS. It was located in the cholangiocytes of liver and then, secreted as exosome into the serum. PICALM-AU1 carrying serum exosomes induced endothelial-mesenchymal transition (EndMT) of PMVECs and promoted lung injury in vivo and in vitro. Furthermore, overexpression of PICALM-AU1 significantly suppressed miR144-3p and subsequently induced ZEB1 expression. Taken together, our findings identified cholangiocyte-derived exosomal lncRNA PICALM-AU1 plays a critical role in the EndMT of HPS lung. And PICALM-AU1 represents a noninvasive biomarker and potential therapeutic target for HPS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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