METABOLISM AND EFFECTS OF GONADOTROPIN RELEASING HORMONE (GnRH) IN CHILDREN AND ADULTS
| Autor: | L Edward Clemens, William J. Oliver, Mara E. Markovs, Robert P. Kelch |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
endocrine system
medicine.medical_specialty Adult male Dose business.industry Serum gonadotropin Endogeny Gonadotropin-releasing hormone Metabolism Specific radioimmunoassay Endocrinology Initial distribution Internal medicine Pediatrics Perinatology and Child Health Medicine business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Pediatric Research. 8:370-370 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-197404000-00180 |
| Popis: | The purpose of this study was to compare the metabolism and effects of synthetic GnRH (Parke-Davis) in children and adults. Eight prepubertal children, 1 pubertal male, and 1 adult male received 10μg/m2 i.v.; 2 adult females were given 100 μg i.v. Blood samples were drawn at frequent intervals. GnRH concentrations were determined by a highly specific radioimmunoassay. Sensitivity of this assay is 1 pg/tube or 5 pg/ml plasma. Serum LH and FSH were determined by RIA. No correlation was found between physiological state or serum gonadotropin values, and endogenous GnRH values: n=64, X=11±1.2 (SE) pg/ml. Many plasma samples fell beneath the sensitivity of the assay. Peak GnRH concentrations occurred at 1 or 2 min. (4.42±0.4 ng/ml, 10μg/m2, 20 and 19.5 ng/ml, 100μg); baseline values returned by 90 min. Initial t½ was 2.9±.3 min. in children and 3.6±.3 in adults. Initial distribution volumes were also similar; children 6.6±0.8; adults 5.9±0.9 % body weight. The plasma disappearance curve of GnRH was described best by a double exponential function: t1½=2.8±.2 min.; t2½=18.9±.9 min. Blunted serum LH responses were seen in all children when compared to our adult standards. These data indicate: 1) that endogenous GnRH levels are lower than previously reported; 2) children and adults metabolize GnRH similarly and 3) dosages of GnRH in comparative studies should be based on weight rather than surface area. |
| Databáze: | OpenAIRE |
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