Toxicity and local anesthetic activity of diterpenoid alkaloids

Autor:	S. K. Usmanova, R. Sh. Shakirov, K. R. Kasymova, B. T. Salimov, M. N. Sultankhodzhaev, F. N. Dzhakhangirov
Rok vydání:	2007
Předmět:	Lidocaine biology Local anesthetic medicine.drug_class Chemistry Plant Science General Chemistry Pharmacology biology.organism_classification General Biochemistry Genetics and Molecular Biology Terpenoid Delphinium Toxicity medicine Lycoctonine Denudatine Aconitum medicine.drug
Zdroj:	Chemistry of Natural Compounds. 43:581-589
ISSN:	1573-8388 0009-3130
DOI:	10.1007/s10600-007-0197-8
Popis:	The toxicity and local anesthetic activity of 74 diterpenoid alkaloids differing in the nature and position of functional groups in lycoctonine, heteratisine, napelline, hetisane, atisane, and denudatine skeletons and their synthetic derivatives were investigated. Compounds with local anesthetic activity and duration of action surpassing that of cocaine for surface anesthesia and that of novocaine and lidocaine for infiltration and trunk administration were identified. Structural factors affecting the toxicity and local anesthetic activity of the studied compounds were discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6a2624744caced100596c647454fa000 https://doi.org/10.1007/s10600-007-0197-8 Zobrazit plný text záznamu Plný text ve formátu PDF