Synthesis and Crystal Structure of Thiazolopyrimidine Derivatives: Insights into Weak Interactions

Autor:	R. Shashi, Noor Shahina Begum, N. L. Prasad
Rok vydání:	2020
Předmět:	Crystal Crystallography chemistry.chemical_compound Ethanol chemistry Pyrimidine One-pot synthesis Fluorine chemistry.chemical_element General Materials Science General Chemistry Crystal structure Condensed Matter Physics
Zdroj:	Crystallography Reports. 65:1161-1168
ISSN:	1562-689X 1063-7745
DOI:	10.1134/s1063774520070202
Popis:	Thiazolo[3,2-a]pyrimidines namely ethyl 2-acetyl-5-(2-fluorophenyl)-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 3a, ethyl 2-acetyl-5-(3-fluorophenyl)-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 3b, and ethyl 2-acetyl-5-(4-fluorophenyl)-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 3c were obtained by one pot synthesis using substituted 3,4 dihydropyrimidine2-thione (1a–1c) and 3-chloro-2,4-pentanedione in ethanol and characterized by single-crystal X-ray diffraction. The variation in the position of fluorine atom on pyrimidine nucleus and insight into the self-assembly of compounds with varied types of non-covalent interactions has great influence on crystal packing.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6a253818eb15a8549997b12aac6b4e9f https://doi.org/10.1134/s1063774520070202 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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