Characterization of STRO-1 Positive Cells Derived from Human Wisdom Tooth Germs

Autor:	Yoko Iwamatsu-Kobayashi, Masashi Komatsu, Junko Kindaichi, Daisuke Nishihara, Naoki Endo, Koji Kindaichi
Rok vydání:	2012
Předmět:	business.industry Mesenchymal stem cell Dentistry ALIZARIN RED Biology Matrix (biology) Chondrogenesis Cell biology medicine.anatomical_structure Tissue engineering medicine Wisdom tooth Nodule formation Stem cell business
Zdroj:	Interface Oral Health Science 2011 ISBN: 9784431540694
DOI:	10.1007/978-4-431-54070-0_27
Popis:	Recently, the research on the stem cells is developing rapidly in the odontology. Mesenchymal stem cells (MSCs) have the possibility useful for the stem cell treatment and the tissue engineering. STRO-1 is one of the mesenchymal stem cell markers. In this study, we examined the characterization of STRO-1 positive cells derived from human wisdom tooth germs (hWTGs) compared with STRO-1 negative cells. As positive control, we used human mesenchymal stem cells (HMSC) on purchase. STRO-1 positive cells derived from hWTGs showed Alcian blue positive matrix like HMSC when cultured in chondrogenic induction medium. STRO-1 negative cells from hWTGs did not show such matrix. Nodule formation stained with Alizarin red was performed not only by STRO-1 positive cells but also STRO-1 negative cells cultured in osteogenic induction medium. It is suggested that STRO-1 positive cells derived from hWTGs are useful for the stem cell treatment and the tissue engineering.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6a22dde0105257d7f01f9b6af3641424 https://doi.org/10.1007/978-4-431-54070-0_27 Zobrazit plný text záznamu