Manganese Dioxide Nanostructures as a Novel Electrochemical Mediator for Thiol Sensors

Autor:	Serguei V. Savilov, E. A. Dontsova, Evgeniy G. Evtushenko, Valery V. Lunin, A. P. Nazarov, A. V. Eremenko, S. V. Amitonov, Ilya N. Kurochkin, L. F. Martynova
Rok vydání:	2012
Předmět:	Detection limit chemistry.chemical_classification Inorganic chemistry chemistry.chemical_element Manganese Electrochemistry Reference electrode Analytical Chemistry Catalysis Thiocholine chemistry Electrode Thiol
Zdroj:	Electroanalysis. 24:573-580
ISSN:	1040-0397
DOI:	10.1002/elan.201100535
Popis:	Nanoparticles of various manganese dioxide crystalline modifications (amorphous, β-phase, and γ-phase) were compared with respect to their mediator properties in electrochemical detection of thiols. The highest catalytic activity towards thiocholine, cysteine, and glutathione was demonstrated by screen-printed graphite electrodes modified with γ-MnO2 at the optimized working potential of 450 mV versus the Ag/AgCl reference electrode. High sensitivity of γ-MnO2 modified electrodes towards thiocholine (345 mA cm2/M) and therefore low detection limit of butyrylcholinesterase (1 pM) enabled their use for subnanomolar detection of an organophosphate pesticide diazinon, an irreversible inhibitor of butyrylcholinesterase. The detection limit for diazinon was estimated as 0.6 nM with assay duration of less than 15 min.
Databáze:	OpenAIRE
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