From the gut to bone: connecting the gut microbiota with Th17 T lymphocytes and postmenopausal osteoporosis
Autor: | Joseph A. Lorenzo |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
medicine.medical_specialty medicine.drug_class Osteoporosis Gut flora Postmenopausal osteoporosis 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine medicine biology business.industry General Medicine biology.organism_classification medicine.disease Menopause 030104 developmental biology medicine.anatomical_structure Endocrinology Estrogen 030220 oncology & carcinogenesis Tumor necrosis factor alpha Bone marrow business hormones hormone substitutes and hormone antagonists |
Zdroj: | Journal of Clinical Investigation. 131 |
ISSN: | 1558-8238 0021-9738 |
Popis: | Osteoporosis is a serious clinical problem that often follows the accelerated bone loss that occurs after the estrogen withdrawal of menopause. In order to better understand the mechanism that produces estrogen withdrawal-induced bone loss, Yu and Pal et al., as reported in this issue of the JCI, examined mice that underwent ovariectomy (OVX). In C57BL/6 mice with enhanced Th17 cells in gut tissue, the authors demonstrated that OVX increased migration of TNF-expressing Th17 cells from the gut to the bone marrow. Furthermore, they found that manipulation of the pathways by which lymphocytes migrate and home to bone marrow prevented the increase of TNF+, Th17 cells in bone marrow after OVX in mice and the trabecular, but not cortical, bone loss in this model. These results argue that interactions of the gut microbiota with the immune system are involved in the effects of estrogen withdrawal on trabecular bone. |
Databáze: | OpenAIRE |
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