| Popis: |
Adipose tissue is in many regards an ideal filler for clinical practice. It is often abundant, can be collected with minimal donor site morbidity, and is valued for both its aesthetic appeal and its biocompatibility. Fat, however, functions as far more than filler and is unique in its ability to improve tissue quality. The mesenchymal niche of adipose tissue, that of the adipose-derived stem cells (ASCs), is a potent immunomodulatory, proangiogenic, and regulatory population within the stroma of whole adipose. The potency of these cells is such that several techniques have been developed to both maximize ASC viability at time of harvest and further enrich adipose autograft with ASCs to potentiate the ability of the grafts to integrate and improve the function of surrounding structures. Here, we will discuss the current state of fat grafting and ASCs in the clinical sphere, with a focus on current technologies, indications, and new developments likely to reach our patients in the near future. |
