A novel and efficient one-pot synthesis of furo[3′,4′:5,6]pyrido[2,3-c]pyrazole derivatives using organocatalysts

Autor:	Zhi-Bin Huang, Daqing Shi, Min Ji, Chun-Ling Shi, Sung Hong Kim, Shun-Jun Ji
Rok vydání:	2008
Předmět:	chemistry.chemical_compound chemistry Yield (chemistry) Organic Chemistry Drug Discovery Thiaproline One-pot synthesis Proline Pyrazole Catalytic efficiency Cinchonidine Biochemistry Combinatorial chemistry
Zdroj:	Tetrahedron. 64:2425-2432
ISSN:	0040-4020
DOI:	10.1016/j.tet.2007.12.053
Popis:	A novel approach to one-pot synthesis of dihydrofuro[3′,4′:5,6]pyrido[2,3-c]pyrazole and indeno[2′,1′:5,6]pyrido[2,3-c]pyrazole derivatives have been investigated using organocatalysts that are recyclable. This new protocol has the advantages of environmental friendliness, higher yield, low cost, as well as convenient operation. The catalytic efficiency of various small organocatalysts such as l -proline, trans-4-hydroxy- l -proline, l -thiaproline, cinchonidine, (+)-cinchonine, and dl -2-phenylglycine has also been studied.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6a01411e2d2a829ed81564c78f730c41 https://doi.org/10.1016/j.tet.2007.12.053 Zobrazit plný text záznamu Full Text from ScienceDirect