Benzolactams as non-peptide cholecystokinin receptor ligands
| Autor: | Mark G. Bock, Stephen B. Freedman, Robert M. DiPardo, Victor J. Lotti, Raymond S.L. Chang, Roger M. Freidinger, D. F. Veber |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Chemistry
digestive oral and skin physiology Organic Chemistry Clinical Biochemistry Pharmaceutical Science Peptide hormone digestive system Biochemistry Non peptide Cholecystokinin receptor Drug Discovery Molecular Medicine Receptor Cholecystokinin A receptor Molecular Biology hormones hormone substitutes and hormone antagonists Cholecystokinin |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:871-874 |
| ISSN: | 0960-894X |
| Popis: | A series of 1,3-substituted benzolactams are reported which are nonpeptidal receptor ligands of the peptide hormone cholecystokinin (CCK). These compounds are composites of potent, selective benzolactam CCK-A antagonists and unique structural elements which have been demonstrated to enhance the affinity of certain 1,4-benzodiazepine CCK-A antagonists for the CCK-B receptor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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