ChemInform Abstract: Reaction of 4-Ethoxy-2-(2,3,3-trichloro-1-nitro-2-propenylidene)benzazetine with Methyl- and Phenyllithium

Autor:	A. A. Yanuchok, Vladimir I. Potkin, R. V. Kaberdin, V. A. Knizhnikov
Rok vydání:	2010
Předmět:	Substitution reaction chemistry.chemical_compound chemistry Yield (chemistry) Chlorine atom Alkoxy group Nitro Organic chemistry Methyllithium General Medicine Medicinal chemistry Phenyllithium
Zdroj:	ChemInform. 32
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200152097
Popis:	The reactions of 4-ethoxy-2-(2,3,3-trichloro-1-nitro-2-propenylidene)benzazetine with methyl- and phenyllithium at a ratio of 1:2 result in replacement of one chlorine atom and formation, respectively, of 4-ethoxy-2-(2,3-dichloro-3-methyl-1-nitro-2-propenylidene)benzazetine and 4-ethoxy-2-(2,3-dichloro-1-nitro-3-phenyl-2-propenylidene)benzazetine in 45 and 52% yield. With excess phenyllithium (reactant ratio 1:5), a mixture of products is formed due to replacement of one, two, and three chlorine atoms by phenyl groups. An analogous reaction with methyllithium is nonselective.
Databáze:	OpenAIRE
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