Effect of LY 171555 and CY 208-243 on tremor suppression in the MPTP monkey model of parkinsonism
| Autor: | René Boucher, Paul J. Bédard, Baltazar Gomez-Mancilla |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
D2 agonist
Agonist medicine.medical_specialty medicine.drug_class Chemistry Parkinsonism medicine.medical_treatment MPTP CY-208 243 Pharmacology medicine.disease Dopamine agonist Rest tremor nervous system diseases chemistry.chemical_compound Endocrinology Anticonvulsant Neurology Internal medicine medicine Neurology (clinical) medicine.drug |
| Zdroj: | Movement Disorders. 7:43-47 |
| ISSN: | 0885-3185 |
| DOI: | 10.1002/mds.870070108 |
| Popis: | The antitremor effect of the D2 agonist LY 171555 and of the D1 agonist CY 208-243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest termor in the limbs. The D2 agonist suppressed rest tremor in a dose-dependent fashion. The D1 agonist by itself had no effect but it potentiated the effect of a small dose of LY 171555. |
| Databáze: | OpenAIRE |
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