A novel reaction of 2-phenacyl mercaptoimidazole with acetic anhydride: formation of an imidazothiazole with loss of a phenyl group

Autor:	Shashiprabha, Suresh P. Nayak, K Sundarraja Rao, K Shridhara, Kuppuswamy Nagarajan, T. N. Guru Row, Sajesh P. Thomas
Rok vydání:	2020
Předmět:	010405 organic chemistry Hydrobromide General Chemistry Crystal structure 010402 general chemistry Ring (chemistry) Phenacyl 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Acetic anhydride Chalcogen chemistry Phenyl group Molecule
Zdroj:	Journal of Chemical Sciences. 132
ISSN:	0973-7103 0974-3626
DOI:	10.1007/s12039-020-01824-y
Popis:	Attempted cyclodehydration of phenacyl mercaptoimidazole hydrobromide with acetic anhydride gave an abnormal product lacking the phenyl group. The molecular structure is confirmed using X-ray crystal structure studies. Phenacyl mercaptobenzimidazole hydrobromide behaved similarly. Analysis of crystal structure revealed an intermolecular S…Br chalcogen bonding interaction. The cylization reaction of 2-phenacylmercaptoimidazole hydrobromide is carried out using acetic anhydride, afforded an unexpected imidazothiazole lacking a phenyl ring. The generality of the reaction is confirmed by a similar reaction which was carried out with phenacylmercaptobenzimidazole and yielded similar product
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::69e302bbcd7ab85280a91470c4415fd3 https://doi.org/10.1007/s12039-020-01824-y Zobrazit plný text záznamu Full text from SpringerLink