Novel Quinazoline Derivatives Bearing a Sulfapyridine Moiety as Anticancer and Radiosensitizing Agents

Autor:	Helmi I. Heiba, Fatma A. Ragab, Mostafa M. Ghorab, Ahmad A. Bayomi
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Stereochemistry Organic Chemistry Sulfapyridine In vitro Sulfonamide Cell killing chemistry In vivo medicine Moiety Doxorubicin Radiosensitizing Agent medicine.drug
Zdroj:	Journal of Heterocyclic Chemistry. 51:E255-E262
ISSN:	0022-152X
DOI:	10.1002/jhet.1830
Popis:	Quinazoline derivatives posses many types of biological activities and have recently been reported to show substantial antitumor activity in vitro and/or in vivo. There is a variety of mechanisms for their anticancer activity. The present work reports the possible utility of methyl anthranilate in the synthesis of some new quinazoline derivatives, bearing a substituted sulfonamide moiety. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against human liver cancer cell line, using doxorubicin as a reference drug. In addition, the most active compounds 14 and 15 were selected and evaluated for their ability to enhance the cell killing effect of γ-radiation.
Databáze:	OpenAIRE
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