Age-related biochemical and histological changes in the soleus muscle of male mice
| Autor: | Khairat B. El-Baradie, Amira R. Hammad, Samaa M. Bakr, Abeer A. Alm-Eldeen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Soleus muscle
chemistry.chemical_classification medicine.medical_specialty business.industry Healthy subjects Skeletal muscle Male mice medicine.disease Lipid peroxidation chemistry.chemical_compound medicine.anatomical_structure Endocrinology Enzyme chemistry Internal medicine Sarcopenia Age related medicine business |
| Zdroj: | Delta Journal of Science. 41:109-115 |
| ISSN: | 2735-5306 |
| DOI: | 10.21608/djs.2020.139233 |
| Popis: | During aging, skeletal muscle is subjected to progressiveloss of muscle mass and strength (sarcopenia) and a decline in thefunctional ability. The reduction in the antioxidative capacity ofthe skeletal muscle resulting in an abnormal accumulation of thereactive oxygen species (ROS) that is one of the possible causesof the decline in muscle performance. In this study thehistological changes in the soleus muscles of male mice at the ageof 1st and 15th old were examined and the activities of theantioxidant enzymes, CAT and SOD, non- enzymatic antioxidantGPH and MDA level were measured to clarify the age-relatedchanges in healthy subjects. Results showed that there is asignificant reduction (P ≤ 0.05) in the antioxidants SOD, CATand GPH and there is a significant increase (P ≤ 0.05) in MDAlevel at the age of 15th month when compared to 1st month old.We concluded that the activities of the antioxidants were affectedby aging. Moreover, there is age- related lipid peroxidation. |
| Databáze: | OpenAIRE |
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