Et2 NH-Mediated 1,3-Dipolar Cycloaddition: Synthesis of 1-(2-(Organylselanyl)pyridin-3-yl)-1H -1,2,3-triazole-4-carboxylate Derivatives
| Autor: | Diego Alves, Nelson M. Nascimento, Rafael Luque, Gelson Perin, Luis Fernando B. Duarte, Ricardo F. Schumacher |
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| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
1 2 3-Triazole 010405 organic chemistry Substituent Alkyne General Chemistry 010402 general chemistry 01 natural sciences Medicinal chemistry Cycloaddition 0104 chemical sciences chemistry.chemical_compound chemistry Organocatalysis 1 3-Dipolar cycloaddition Organic chemistry Carboxylate Azide |
| Zdroj: | ChemistrySelect. 2:6645-6649 |
| ISSN: | 2365-6549 |
| DOI: | 10.1002/slct.201701280 |
| Popis: | The use of Et2NH as organocatalyst for 1,3-dipolar cycloadditions of 3-azido-2-organylselanyl-pyridines with 1,3-dicarbonyl compounds is reported in this work. Reactions were conducted using DMSO as solvent at room temperature in air. All products were obtained in good to excellent yields. The reaction took place under very mild conditions and tolerated a range of functionalities. 1-(2-(Phenylselanyl)pyridin-3-yl)-1H-1,2,3-triazole-4-carboxylate containing an alkyne substituent was selected as candidate for a Cu-catalyzed azide alkyne cycloaddition reaction, affording the bis-triazole in good yields. |
| Databáze: | OpenAIRE |
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