First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows
| Autor: | Xianming Xia, Jie Tian, Yue Chen, Cheng Fang, Xingwang Sun, Zhen Cheng, Meishan Cai, Tie-Jun Zhou, Chongwei Chi, Zhenhua Hu, Song Su, Xiaojing Shi, Zeyu Zhang, Yuanxue Zhang, Bo Li, Sanjiv S. Gambhir, Caiguang Cao, Pan He, Cong Li |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Fluorescence-lifetime imaging microscopy Tumour surgery business.industry Near-infrared spectroscopy Multispectral image Biomedical Engineering Medicine (miscellaneous) Bioengineering First in human Fluorescence Computer Science Applications 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Medicine In patient business Nuclear medicine Indocyanine green 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Nature Biomedical Engineering. 4:259-271 |
| ISSN: | 2157-846X |
| DOI: | 10.1038/s41551-019-0494-0 |
| Popis: | The second near-infrared wavelength window (NIR-II, 1,000–1,700 nm) enables fluorescence imaging of tissue with enhanced contrast at depths of millimetres and at micrometre-scale resolution. However, the lack of clinically viable NIR-II equipment has hindered the clinical translation of NIR-II imaging. Here, we describe an optical-imaging instrument that integrates a visible multispectral imaging system with the detection of NIR-II and NIR-I (700–900 nm in wavelength) fluorescence (by using the dye indocyanine green) for aiding the fluorescence-guided surgical resection of primary and metastatic liver tumours in 23 patients. We found that, compared with NIR-I imaging, intraoperative NIR-II imaging provided a higher tumour-detection sensitivity (100% versus 90.6%; with 95% confidence intervals of 89.1%–100% and 75.0%–98.0%, respectively), a higher tumour-to-normal-liver-tissue signal ratio (5.33 versus 1.45) and an enhanced tumour-detection rate (56.41% versus 46.15%). We infer that combining the NIR-I/II spectral windows and suitable fluorescence probes might improve image-guided surgery in the clinic. An optical-imaging instrument that integrates a visible multispectral imaging system with the detection of near-infrared fluorescence in the first and second windows aids the fluorescence-guided surgical resection of liver tumours in patients. |
| Databáze: | OpenAIRE |
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