THE USE OF CASTRATE MALE RATS FOR THE ASSAY OF TESTOSTERONE PROPIONATE

Autor:	Harry W. Hays, Donald R. Mathieson
Rok vydání:	1945
Předmět:	Testosterone propionate medicine.medical_specialty Testosterone (patch) chemistry.chemical_compound Endocrinology Castration Seminal vesicle medicine.anatomical_structure chemistry Internal medicine Male rats medicine Relative potency
Zdroj:	Endocrinology. 37:275-279
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo-37-4-275
Popis:	IN A PREVIOUS COMMUNICATION Hays & Mathieson (1945) have (1) demonstrated that it is more convenient and leads to equally satisfactory results when castrate male rats are used insteadof immature rats for assay of testosterone propionate; (2) shown that rats castrated at 26 to 29 days of age can be used for assay 14 to 300 days after castration; (3) obtained data which shows that seventy-two hours after the injection of testosterone propionate the difference in seminal vesicle response to doses ranging from 0.1 mgm. to 1.0 mgm. are more significant than at forty-eight, ninety-six or one-hundred and twenty hours. As a result of these experiments we have developed a method of assay for testosterone propionate using the new experimental design proposed by Bliss (1945) for determining the relative potency of drugs. This method together with detailed results of arepresentative assay is presented here.
Databáze:	OpenAIRE
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