Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy
Autor: | T. S. Kurkin, Matsumura Akira, P. A. Khaptakhanova, Ludmila V. Mechetina, Alexander Zaboronok, O. Yu. Volkova, S. A. Uspenskii, V. V. Kanygin, Alexander V. Taranin, S. Yu. Taskaev |
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Rok vydání: | 2020 |
Předmět: | |
Zdroj: | Doklady Chemistry. 491:45-48 |
ISSN: | 1608-3113 0012-5008 |
Popis: | A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability. |
Databáze: | OpenAIRE |
Externí odkaz: | |
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