Elemental Boron Nanoparticles: Production by Ultrasonication in Aqueous Medium and Application in Boron Neutron Capture Therapy

Autor:	T. S. Kurkin, Matsumura Akira, P. A. Khaptakhanova, Ludmila V. Mechetina, Alexander Zaboronok, O. Yu. Volkova, S. A. Uspenskii, V. V. Kanygin, Alexander V. Taranin, S. Yu. Taskaev
Rok vydání:	2020
Předmět:	inorganic chemicals Isotope Aqueous medium 010405 organic chemistry Chemistry Sonication Radiochemistry Nanoparticle chemistry.chemical_element General Chemistry Liquid medium Fractionation 010402 general chemistry 01 natural sciences 0104 chemical sciences Neutron capture Boron
Zdroj:	Doklady Chemistry. 491:45-48
ISSN:	1608-3113 0012-5008
Popis:	A method for producing elemental boron nanoparticles with a size of less than 100 nm by ultrasonic dispersion in a liquid medium and subsequent cascade fractionation is described. The resulting boron nanoparticles were used as a target for boron neutron capture therapy (BNCT). According to the results of an experimental preclinical study of BNCT with the synthesized boron nanoparticles, neutron irradiation for 1 h of T98G human glioma cells pre-incubated in a medium with boron nanoparticles (10, 20, and 40 ppm in terms of boron-10 isotope) leads to a significant suppression of cell viability.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::69b8129ad6dcf6ae207f83075a29b89f https://doi.org/10.1134/s0012500820030027 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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