Vitamin D3as a novel regulator of basic fibroblast growth factor in chronic rhinosinusitis with nasal polyposis

Autor:	Timothy L. Smith, Zachary M. Soler, Jess C. Mace, Jennifer K. Mulligan, James R. Yawn, Nathan B. Sautter, E. Ritter Sansoni, Lauren A. Lawrence, Rodney J. Schlosser
Rok vydání:	2015
Předmět:	animal structures business.industry Basic fibroblast growth factor Inflammation Disease respiratory system medicine.disease Mucus chemistry.chemical_compound Otorhinolaryngology chemistry Immunology otorhinolaryngologic diseases medicine Vitamin D and neurology Immunology and Allergy Nasal polyps medicine.symptom Sinusitis Cholecalciferol business
Zdroj:	International Forum of Allergy & Rhinology. 5:191-196
ISSN:	2042-6976
DOI:	10.1002/alr.21474
Popis:	Background The immunopathogenesis of chronic rhinosinusitis (CRS) is largely unknown, but it is thought that different inflammatory profiles are responsible for the different CRS subtypes. 25-hydroxyvitamin-D (25-VD3) has been shown to alter inflammatory mediators in other disease processes and 25VD3 deficiency is associated with CRS with nasal polyps (CRSwNP), but it is unknown if 25VD3 levels impacts local inflammation in CRS. This study investigated the correlation between plasma 25-VD3 and sinonasal mucus MCP-1, RANTES and bFGF levels in patients with CRS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::69b2e5b11cb7fe58ffb51cf3f3e3a4a5 https://doi.org/10.1002/alr.21474 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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