Behavioral Reactions, Corticosterone Concentrations, and the Expression of Cytokine Genes in Experimental Postviral Fatigue in Animals
| Autor: | T. A. Filatenkova, E. G. Rybakina, E. E. Fomicheva, S. N. Shanin, E. V. Dmitrienko |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Spleen Postviral fatigue 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Corticosterone Interferon Internal medicine Chronic fatigue syndrome medicine Endocrine system 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology skin and connective tissue diseases business.industry General Neuroscience 05 social sciences medicine.disease medicine.anatomical_structure Endocrinology chemistry Hypothalamus Immunology sense organs business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuroscience and Behavioral Physiology. 46:28-35 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-015-0194-5 |
| Popis: | The aim of the present work was to study the processes of the interaction between the nervous, endocrine, and immune systems in experimental postviral fatigue, by studying behavioral reactions, changes in blood corticosterone levels, and changes in the level of expression of the IL-1β and IL-10 genes in the hypothalamus and interferon-α in the hypothalamus and spleen in rats. Decreases in the physical activity displayed by the animals were seen on days 7 and 10 after modeling of experimental postviral fatigue by i.p. administration of poly I:C, along with increases in the blood corticosterone concentration and increases in the expression of genes for pro- and anti-inflammatory cytokines and interferon. Repeat administration of poly I:C was followed by increases in physical activity and repeated delayed changes in the functions of the endocrine and immune systems. The changes seen in the ratio of changes in the study parameters provides evidence of the need for complex studies of changes in the functions of the nervous, endocrine, and immune systems in this disease. |
| Databáze: | OpenAIRE |
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