Results of treatment of conjunctival melanoma in 61 consecutive patients

Autor: Bożena Romanowska-Dixon, Arkadiusz Pogrzebielski, Anna Bogdali, A Napora‐Krawiec
Rok vydání: 2008
Předmět:
Zdroj: Acta Ophthalmologica. 86
ISSN: 1755-375X
DOI: 10.1111/j.1755-3768.2008.4462.x
Popis: Purpose Analysis of patients with conjunctival melanoma. Methods Retrospective analysis of 61 consecutive patients with histopathologic diagnosis of conjunctival melanoma treated between 1991-2007 at the Department of Ophthalmology and Ocular Oncology of Jagiellonian University in Krakow. There were 30 (49.2%) women and 31 (50.8%) men in mean age of 57.6 years (25-89). Results The tumors involved in 29 cases right eye and in 32 cases left eye. 26 (42.6%) melanomas were located in temporal quadrant; 37 (60.6%) tumors involved limbus and 22 (36.1%) bulbar conjunctiva; in 2 (3.3%) patients tumors infiltrated tarsal conjunctiva. 53 tumors (86.9%) were pigmented, 5 (8.2%) - amelanotic and 3 tumors (4.9%) - mixed. In 59 (96.7%) patients the tumors were nodular and in 2 (3.3%) diffuse, superficial. In all cases surgical excision was performed and in 44 (73.13%) cases adjunctive Ru-106 brachytherapy. In 20 (32.7%) cases recurrence of melanoma necessitating secondary treatment was observed. The mean time to recurrence was 24.65 months (2-91). In 5 (8%) cases documented metastasis occurred. Among all patients 5 (8%) died because of metastatic disease, 3 because of other reasons. 6 cases were lost to follow-up because they moved to other countries. Conclusion Conjunctival melanoma most commonly occurs in form of a melanocytic, nodular tumor localized in corneal limbus and bulbar conjunctiva. Local recurrence of the tumor may be expected despite the surgical excision combined with adjunctive therapies.
Databáze: OpenAIRE
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