STUDY THE EFFICACY OF CHRONIC INTERMITTENT INTRAVENOUS INSULIN INFUSION THERAPY OVER AND ABOVE CONVENTIONAL TREATMENT IN PATIENTS OF DIABETIC AUTONOMIC NEUROPATHY

Autor:	Singh Ak, Maheshwari Pk, Prabhat Agrawal, Saurabh Bansal, Shweta Agarwal, Deepak Purohit, Prashant Prakash
Rok vydání:	2018
Předmět:	Pharmacology Diabetic Autonomic Neuropathy Constipation business.industry Pharmaceutical Science medicine.disease Diarrhea Erectile dysfunction Pharmacotherapy Refractory Infusion therapy Anesthesia Diabetes mellitus medicine Pharmacology (medical) medicine.symptom business
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. 11:227
ISSN:	2455-3891 0974-2441
DOI:	10.22159/ajpcr.2018.v11i9.25613
Popis:	Objective: This study aims to emphasize the importance of chronic intermittent intravenous insulin infusion therapy (CIIIT) over and above conventional treatment in patients with diabetic autonomic neuropathy.Methods: In our study, we had 50 patients; most of the patients were in the age group of 30–50 years and sex ratio for male:female was 3:2. The patients were divided into two groups. One group which received monthly CIIIT for 8 h per month for 6 months (Group-1) whereas other group did not receive it (Group-2). However, both groups continued their old treatment (oral hypoglycemic or subcutaneous insulin).Results: On 12-month follow-up, in Group-1, palpitation improved in 16 of 17 (94.1%), giddiness improved in 12 of 20 (60.0%), constipation improved in 7 of 12 (58.3%), diarrhea improved in 7 of 8 (87.5%), erectile dysfunction improved in 3 of 5 (60.0%), abdominal fullness improved in 12 of 17 (70.5%), and abnormal sweating improved in 6 of 20 (30%). In comparison to this, in Group 2, palpitation improved in 6 of 19 (31.5%), giddiness improved in 2 of 15 (13.3%), constipation improved in 3 of 13 (23.0%), diarrhea improved in 3 of 7 (42.8%), erectile dysfunction improved in 3 of 5 (20.0%), abdominal fullness improved in 4 of 13 (13.7%), and abnormal sweating improved in 5 of 17 (29.4%).Conclusion: At the conclusion of our study, we found that patients, who were previously refractory to conventional pharmacotherapy, showed a considerable response to CIIIT with most patients giving a history of improvement in their symptoms after therapy and during follow-up. Therefore, it is recommended that patients presenting with complaints of diabetic autonomic neuropathy should be managed by CIIIT rather than the conventional pharmacological therapies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::69a9804af5cb2f68c2677e496d35e441 https://doi.org/10.22159/ajpcr.2018.v11i9.25613 Zobrazit plný text záznamu