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[ 18 F] 2-Fluoro-2-deoxy- d -glucose (FDG) and l -[methyl- 1 1 C]-methionine (MET) are the most widely used tracers for oncological PET studies. MET has the potential to image the increased dependency of malignant tumors on methionine, although the exact mechanisms of MET uptake in cancer cells are not fully understood. To date, a number of reports suggested that the diagnostic value of MET was comparable to FDG and that MET may be promising in oncology. However, it has been uncertain in what tumor and for what purpose MET has advantages over FDG. Current results of MET-PET in over 400 patients at Hokkaido University Hospital from Jan. 2002 to Sep. 2003 suggest that MET is favorable as an alternative as well as an adjunctive to FDG-PET. |
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