| Popis: |
Chronic inflammatory state is linked to the emergence of hepatocellular carcinoma, one of the most common and aggressive cancers worldwide. The complex microenvironment of tumor changes dynamically and consequently affects the pathological process. Understanding the immunological milieu of tumor in hepatocellular carcinoma can have crucial repercussions on how we see liver cancer and help plan for future cancer treatments. Taking part in this dynamic microenvironment, macrophages play a vital role in tumor growth and proliferation, cancer survival, metastasis and angiogenesis. In this review, we discuss the place and the current understanding of tumorassociated macrophages and their role in the process of hepatocarcinogenesis. In addition, we present directions for research targeting macrophage plasticity for future anti-tumor therapeutic approaches. |
