Preparation and Enantioseparation of Polymer-type Chiral Stationary Phases Derived from (1S,2R)-(+)-2-Amino-1,2-diphenylethanol

Autor:	Zheng-Wu Bai, Shi-Rong Li, Chuan-Qi Yin, Shao-Hua Huang, Zhi-Quan Pan, Jun-Yi Zhang
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Chromatography Silica gel Clinical Biochemistry Pharmaceutical Science Polymer Biochemistry High-performance liquid chromatography Analytical Chemistry Chiral column chromatography chemistry.chemical_compound chemistry Organic chemistry Terephthaloyl chloride Enantiomer Chiral derivatizing agent Polyurethane
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 31:2554-2574
ISSN:	1520-572X 1082-6076
DOI:	10.1080/10826070802352744
Popis:	Polymers 1 and 2 were synthesized, respectively, by the copolymerization of (1S,2R)-(+)-2-amino-1,2-diphenylethanol with 1,4-phenylene diisocyanate; and (1S,2R)-(+)-2-amino-1,2-diphenylethanol with 1,4-phenylene diisocyanate and terephthaloyl chloride. The corresponding chiral stationary phases, CSPs 1 and 2, were prepared by immobilizing these polymers on 3-aminopropyl silica gel. The enantioseparation ability of obtained chiral stationary phases was evaluated with a series of chiral analytes. The effects of organic additives, mobile phase composition, temperature, and substituents of chiral analytes on enantioseparation were investigated in high performance liquid chromatography. The preliminary studies demonstrated that the enantioseparation ability could be resumed, although the chiral stationary phase experienced acidic mobile phase.
Databáze:	OpenAIRE
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